The Danger In Writing New Laws To Correct Behavior Is That:

Less than 500 years ago, science was a dangerous business. In 1600, the Italian monk Giordano Bruno was sentenced to death and burned at the stake because he believed in free thinking in philosophy and science. Galileo Galilei narrowly avoided the same fate but only by publicly renouncing his support of Copernicus' heliocentric view. Of course, the days of autodafés are over and modern science has an important influence on the development of society as a whole, compared with the days of the ill-fated Bruno. But while scientific progress has been rapid and astonishing, it is still disturbing for those people who feel excluded from the debate surrounding the application of science in new technologies and products. Furthermore, as scientific progress becomes increasingly fundamental to society, it is constantly challenging if not completely clashing with long-held beliefs concerning our ethical values. It is, therefore, necessary to conduct ethical discussions in order to adapt the use of scientific knowledge—namely new forms of technology—to a general context that is in agreement with the basic principles of our civilisation. Scientists should be concerned about the use of scientific knowledge and they should address the ensuing ethical questions, both in general terms and in terms of their own work.

The word 'ethics' comes from the Greek word 'ethos', meaning custom or behaviour. The concept of ethics was originally proposed by the Greek philosopher Aristotle for the discussion of philosophical questions relating to daily life: the 'ethike theoria' deals with the study of, and gives criteria for the evaluation of human behaviour. Since then, ethics has become one of the major topics in Western philosophy when debating social and individual values, their relationship and their hierarchy in society. Today, the meaning of 'ethics' is more or less equivalent to that of 'morals', which comes from the Latin word 'mos, moris' and also means custom or behaviour, but at a more personal level. Moralists, such as Nietzsche, Santayana and Russell, claim that ethical values are rather personal interpretations, deliberations or preferences and not general principles that can be proven true or false. John Ziman, the former Chairman of the Council for Science and Society, interprets ethics not as an abstract discipline but as a way of dealing with differing opinions that arise when traditional values are faced with new realities (Ziman, 2001).

Indeed, discussions about the ethical foundations of a society and their re-interpretation usually take place when traditional customs or behaviours are challenged by new developments. In a static society, values are well codified, usually by religion or by tradition. This is true for numerous ancient societies, which remained unchanged for centuries. But wars, invasions or a new culture or religion usually prompt the evaluation of the traditional values. For instance, the French and Russian revolutions in Europe as well as colonialism on other continents effectively upset and irrevocably changed society's traditional values to varying degrees. Later in the 20^th century, the creation of new technologies through scientific progress had a profound effect on society, public opinion and our way of life and has thus sparked discussion on how to use this knowledge (http://www.pugwash.org/). In the 1950s and 1960s, ethical discussions dealt mainly with the use of physics and engineering for the construction of new weapons (http://www.lasg.org/pledge/pledgefrm_a.htm l). In the 1970s and 1980s, the focus was on environmental problems. Today, most ethical discussions deal with the progress in biology and its consequences for society.

Scientific progress, the driving force for the majority of the changes witnessed in the 20^th century, requires a critical mind, free of prejudice and open to new ways of thinking. The rapid development of modern science since the Renaissance is due mainly to the postulate that scientific theories should be independent of theological or religious beliefs. In the 17^th and 18^th century, knowledge was mainly exchanged through scientific academies which disseminated new theories and thus accelerated scientific progress. At the beginning of the 19^th century, there was a remarkable rise in academic research at universities, also labelled 'pure' research. Scientists were not interested in practicalities and were not concerned with the technological applications of the results of their endeavours. They proclaimed the neutrality of science, stating that the advancement of knowledge could not be considered good or bad. In this context, science was not responsible for its applications, and even less for their subsequent use.

Industrial research, on the other hand, was radically different. Although based on the same knowledge, it had completely different aims and rules. Results were not owned by scientists, but were the property of the industries financing the research. The aim was not to acquire new knowledge, but to invent new products in order to increase profits. Ethical problems were considered to be the responsibility of the company and not of the scientists.

As a result, discussions concerning ethical problems were more or less absent from both realms. In academia, scientists were indifferent to the possible consequences of their work and in industry, employers did not consider it appropriate for scientists to worry about ethical problems. Of course, this description of academic and industrial research is schematic and does not truly represent the real world. Nevertheless, it still exists and sways the minds of those who have the greatest influence on our contemporary scientific culture.

Since the 1950s, large changes in the interactions between academic and industrial research have taken place, even in their definition, and ample literature exists on this subject. Scientists in academia receive more financing than in the past. Furthermore, science administrators usually make decisions on the basis of social considerations, namely on the expected contribution to problems such as health, food, energy, etc. Such research policies have an ethical component as they aim to solve social problems. As a consequence, it has become pertinent and necessary to evaluate, from an ethical point of view, not only the use of scientific knowledge, but also its production. Industrial research, on the other hand, has become more sophisticated and its results are often published in peer-reviewed journals. Furthermore, scientists in academia and industry are increasingly collaborating, and this is even encouraged in most countries.

The relationship between public and private research is the source of further ethical issues, which are important not only for the research community, but for all sectors of society. Universities and public research institutes encourage their scientists to request funds from industry and to patent their results. Scientists working in the public sector increasingly own patents or shares, or act as consultants for companies (http://www.cspinet.org/integrity/database.html). These activities are an important source of income as well as expertise and proprietary technology for the universities. Moreover, they are encouraged by politicians since they generate start-up companies and stimulate local economies. Although this phenomenon is considered to be very useful, it can and already has caused conflicts of interest (Cech, 2001; sidebar). There are worries that, especially in clinical research, the conflicts of interest have become so pervasive (Smaglik, 2000) and so difficult to disclose (Holden, 2001; Knight, 2001) that the rate of approval of new drugs will soon begin to diminish (Wadman, 2001).

As an example of the necessity of conducting discussions on ethics, I wish to refer to the debate on embryonic stem cells (Lachmann, 2001; http://bioethics.gov/stemcell_exec_intro.htm). Knowledge concerning human stem cells could be used to devise new therapies that may benefit millions of patients (Vogel, 2001). These totipotent cells could be grown and differentiated in vitro to produce specific cell lines, which could be used as cell transplants, for example to replace 'dopaminergic' neurons for the treatment of Parkinson's disease, or pancreatic cells for the treatment of diabetes. This is a research strategy and not a working technology; it is not clear yet whether this goal will be achieved easily, since the implantation of new cells in an organism may alter mechanisms of cell interaction and metabolic circuits. However, the public debate asks if it is ethical to destroy human embryos in order to gain knowledge for the purpose of curing diseases (Science, 2000). The arguments against the use of embryonic cells essentially deal with the respect for human life and for human dignity (Mieth, 2000). Many critics ask for a moratorium to suspend research with embryonic stem cells and prefer instead the use of adult stem cells or blood cells from the umbilical cords of newborn infants. However, results could possibly be achieved in a shorter time-frame using embryonic cells, and, moreover, it is not yet clear whether adult cells have the same potential to differentiate into various tissues.

I am convinced that this topic is so sensitive because society does not have an informed opinion and therefore still has to find a consensus. Again, this is a question of hierarchy of values: is the life of a frozen embryo more important than a cure for a disease? A moratorium to suspend research using human embryonic cells must include both the public and private domains since to allow the latter to continue would be true hypocrisy. Of course, no restriction should be imposed on research using adult stem cells or embryonic stem cells isolated from animals. But I think it would be difficult to establish such a moratorium for several reasons. First, it should be respected all over the world and not only in some nations. Secondly, it would be difficult to reach a consensus on a moratorium since patient associations and the industrial sector would certainly lobby for the continuation of this research. Thirdly, we should recognise that scientists have an intellectual, but also a practical interest, since results may be obtained more easily with embryonic rather than adult stem cells. Finally, a moratorium would not be an ethically neutral option, since it may delay the possibility of curing patients. Although a moratorium is probably not realistic, it is necessary to find solutions that take into account the ethical problems of all sectors of society. And this requires not only that society becomes more conscious of the different aspects of the issue, but also that scientists become more conscious of the ethical aspects of their work: 'Science sans conscience est la ruine de l'âme' (Rabelais, Gargantua et Pantagruel).

The debate surrounding embryonic stem cells is not the only example of an ethical controversy born out of scientific research. Genetically modified (GM) plants have also stirred a growing public controversy. While stem cell research challenges views on the very nature of humanity itself, the ethical implications of GM plants rather raises questions on how to deal with the environment. Proponents point out the benefits of this research, namely in feeding an ever-increasing human population—particularly in the Third World—while dealing with the environmental problems (Leaver and Trewavas, 2001) created by this very population. The critics want to see GM plants banned forever because they fear irrevocable damage to the environment (Flothmann and van Aken, 2001).

GM crops and the use of embryonic cells are only two examples among the numerous ethical problems and questions arising from the rate of scientific progress and the ensuing new technologies that we must face today (Lenoir, 1996). In the case of stem cells, scientific progress is generating new technologies that are causing ethical problems. But scientific knowledge alone can create ethical problems of its own. In the case of abortion, new insights into embryo development have given fresh arguments to those who want to see abortion banned. In fact, in the past, the embryo and the fertilised egg were considered to be without life or without soul, while today we know much more about their potential. Indeed, it is becoming increasingly necessary for scientists to devote more attention to ethical problems concerning their research and resulting new technologies (Rotblat, 1999a,b). Everybody should be involved, because the solutions to ethical problems that come from scientific progress cannot be imposed by dogma of faith, or by law. It is the civil society, which includes scientists, that must find an acceptable solution. Only then can governments react and draft new laws to address these problems (see also the Center for Applied and Professional Ethics: http://cape. cmsu.edu).

Unfortunately, such a commitment to debate ethical challenges is insufficient at all levels of society and within the scientific community. Furthermore, the conflicts of interest I mentioned above complicate the issue. It is therefore important that governments, public and private funding organisations, scientific societies and the researchers themselves become more sensitive to ethical questions. In the present climate, upholding the neutrality of science would not be amoral, but immoral. Scientists are the first to receive crucial information, sometimes years in advance, about the potential dangers of certain scientific knowledge. I refer, for example, to Niels Bohr and the atomic bomb, to Paul Berg and genetic engineering or to Ian Wilmut and cloning. Thus, the onus is on the scientists to inform the public about the potential dangers of new technologies and to engage the public in debates on how to use their knowledge wisely and in the best public interest (Iaccarino, 2001).

What are the most important ethical implications of scientific research and the development of new technologies? In 1999, UNESCO and ICSU organised a World Conference on Science, for governments to discuss problems regarding science and society. They eventually approved a document, the 'Science Agenda—Framework for Action', that contains a chapter on ethical issues. As this document was approved following thorough consultation with all UNESCO member states and informed discussion with their respective scientific communities, it can be considered a useful reference to identify and deal with ethical problems that stem from scientific research in a general context. Here, I report a summary, in my words, of each paragraph (see sidebar). Obviously, it is necessary to consult the original text for the simple reason that each word was approved after long discussion (http://www.unesco.org/science/wcs/eng/framework.htm).

And how can we make the scientists more sensitive to the ethical implications of their work? I think it is necessary to start from the bottom, namely at the level of individual scientists. The most appropriate context to discuss ethical questions is the annual meetings of scientific societies (Smaglik and Macilwain, 2001). I suggest that participants are asked to propose and discuss ethical commitments, and to decide whether it is necessary to make them obligatory for all members of that particular scientific society. Of course, it is also necessary to invite members of the public, or even critics, in order to appreciate their perceptions and expectations of scientific research. Only in this way can we understand what are the most sensitive issues for researchers and make them more aware of the ethical implications of their work. Researchers, who are often university professors, would then be more prepared to inform their students about ethical problems. Subsequently, it will be possible to come to a more general conclusion at a national, or even better, at an international level. The ethics of science is not a personal problem but a collective problem that involves all scientists at a personal but also at a general level.

We live in a world in which scientific knowledge and new technologies continuously challenge our values. We all have to live our daily lives and make decisions based on the fundamental values of human dignity embedded in our civilisation. Scientists are no exception. Rather, I am convinced that they have an obligation to make a special effort to contribute to this discussion, because they often have more information and more basic knowledge about the very issues that generate these ethical dilemmas.

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World Conference on Science organised by UNESCO and ICSU

Science Agenda—Framework for Action, Chapter 3.2 Ethical issues71. Ethics should be part of the education and training of all scientists.72. Research institutions should foster the study of ethical aspects of scientific work.73. The international scientific community should promote environmental ethics.74. Scientific institutions should comply with ethical norms.75. Governments and civil society should organise debates on the ethical implications of the scientific work.76. Governments and civil society should set up ethics committees.77. UNESCO should strengthen its Bioethics Committee and the World Commission on the Ethics of Scientific Knowledge and Technology.http://www.unesco.org/science/wcs/eng/key_documents.htm

Conflicts of interest

The possibility of using the resources of public institutions for private interests;

Undue influence by the private sector on the establishment of priorities of public research;

Differences of opinion in the use of public structures between scientists having industrial collaborations and scientists receiving only public funds;

Worry among graduate students that their advisor may serve industrial interests and not educational ones;

Difficulties in finding experts free of conflicts of interest.